SEEK: Salford Environment for Expertise and Knowledge
Dr Athar Aziz
Dr Athar Aziz
postal address109, Cockcroft Building, Salford, M5 4WT.
telephone0161 295 5067
Key Memberships
Full Member of Research Centre: Biomedical Research Centre
From September 2015 to present.
From September 2013 to August 2015.
Profile Summary

My interest is to dissect the epigenetic mechanism that block the differentiation in acute myeloid leukaemia using proteomic approaches using in vivo and in vitro profiling of purified genomic loci. A novel drug should target only malignant cells and leave non-malignant cells intact. Current chemotherapeutic approaches used in acute myeloid leukaemia also target normal haematopoietic differentiation. By isolating right epigenetic complex – and targeting it by small molecule inhibitors – we can not only target specifically malignant clone but also leave non-malignant cells intact.

Genetic changes that occur within malignant cells, such as activation of oncogenes or loss of tumour suppressors, are responsible for many aspects of cancer development; however, they are not sufficient. Tumour progression is dependent on ancillary processes provided by cells of the tumour environment but that are not necessarily derived from malignant clone of cells. Inflammation has long been associated with the development and progression of cancer. My interest is to evaluate the role of malignant and non- malignant clone derived macrophages in tumour microenvironment. The model system I am using is chronic haematopoietic malignancies and the bone marrow microenvironment in those malignancies.


Key Qualifications
Key Projects
Kidscan Student Placement Award
Kidscan, 2,000.00.
Principal Investigator: A Aziz (100%).