SEEK: Salford Environment for Expertise and Knowledge
Dr Lucy Smyth
Dr Lucy Smyth
postal addressRoom G44, Peel Building, School of Environment & Life Sciences, University of Salford, Salford, M5 4WT.
email addressl.smyth@salford.ac.uk
telephone+44 (0)161 2955723
Key Memberships
From February 2010 to present.
Full Member of Research Centre: Biomedical Research Centre
From September 2015 to present.
Full Member of Research Centre: Biomedical Research Centre
From June 2015 to August 2015.
Full Member of Research Centre: Parasitology & Disease
From February 2010 to June 2015.
Profile Summary
  • Senior Fellow Higher Education Academy (SFHEA)
  • Fellow Institute of Biomedical Science (FIBMS)
  • Lecturer in Biomedical Science + Human Physiology.
  • Biomedical Science Programme Leader
Research Interests: Fibrosis Inflammation + Repair (FIR) / Respiratory Diseases.
Lung disease is extremely prevelent in the uk, affecting >8 million people and their clinical care comes at great cost to the NHS.  Asthma and COPD (chronic obstructive pulmonary disease) are the two most common conditions each requiring research to further understand the lung pathology and to advance future treatments. 
To do this we have good links with clinical research groups located in local NHS hospitals which enables us to undertake 'translational science' investigations on clinical samples.
 
Two key areas of interest:
 
1.  Lung fibrosis and 'cellular remodelling' events
2.  Altered adaptive immunity associated with lung inflammation
 

 1.  Lung fibrosis is commonly associated with COPD but can also occur without a cause (idiopathic).  Lung epithelia cells normally have the potential to regenerate in response to damage and fibroblasts provide an extracellular scaffold for elasticity.  In fibrotic disease this regeneration becomes defective and accelerated causing the airway thickening. This condition has a very poor prognosis; on average patients survive only 2-3 years from diagnosis.  Research at Salford investigates cellular ‘remodelling’ events in lung fibrosis and evaluates fibrosis reversal strategies.  

 2.  During lung infections airways are characteristically infiltrated by large numbers of T lymphocytes that partly provide our protective immune responses. T lymphocytes have the ability to recognise and aid clearance of previously encountered infections, however, inflammation during the absence of infection (ie in Asthma and COPD) indicates altered adaptive immunity is contributing to the disease pathology.
A family of CD4 T-helper lymphocytes (regulatory T cells or Tregs) can suppress activated lymphocytes.  Tregs are present at inflammatory loci in a number of conditions including COPD, and Asthma but it is not known why the inflammation is ongoing in their presence.
Research at Salford investigates the  to enhance understanding of the role of Tregs in lung disease.
Key Projects
2019
Feb
KidsCan Student Placement Grant 2019
Kidscan, 2,000.00.
Principal Investigator: L Smyth (70%). Co-Investigator: J Wilkinson (30%).
2016
Mar
PhD Studenship (additional funds)
Kidscan, 500.00.
Principal Investigator: L Smyth (100%).
2015
Sep
PhD Studentship
Kidscan, 42,212.00.
Principal Investigator: L Smyth (100%).
2015
Jul
Alterations in autophagy in Frontotemporallobar degeneration: identifying new targets for therapeutic intervention
Alzheimer's Research UK, 80,468.00.
Principal Investigator: G Lace-Costigan (75%). Co-Investigator: L Smyth (25%).
2015
Jun
Kidscan Student Placement Award
Kidscan, 2,000.00.
Principal Investigator: L Smyth (100%).
2015
Jun
Biomedical Vacation Scholarship
Wellcome Trust, 2,000.00.
Principal Investigator: L Smyth (100%).
2014
Sep
2009
Jan
British Association for Lung Research - Vacation Scholarship
British Association for Lung Research, 1,520.00.
Principal Investigator: L Smyth (75%). Co-Investigator: J Allen (25%).
Key Publications
Refereed Journal Articles
Key Presence
Conference Presentations
2009
Jul
2006
Jun
2003
Feb
2001
Aug
2001
Jun
2000
Dec
Consultancy Roles
2007
Sep

Invited GSK consultancy to provide flow cytometric analysis training (Fraunhouf Institute, Hannover, Germany) to initiate a clinical study

 

Internal University Support Received
2011
Sep

3 year sponsorship to support lung fibrosis studies in Salford Fibrosis, Inflammation + Repair group.

2010
Aug

£2000 to support lung fibrosis research.

2010
Jun

Summer vacation bursary to support lung fibrosis research.

Memberships of External Bodies
2006
Sep
2006
Sep
1999
Sep

Committee communications secretary for 1 term and continued membership - present.

1995
Sep

 

British Society for Immunology (BSI): active member of local immunology groups (NE: 1999-2002) and NW (2002-present) and presentations in most BSI annual congresses

Other
2006
Apr

 

 2006-present:

 

International J Cancer(1), European Respiratory Journal(3), Chest(9), Respiratory Research(1), International Journal COPD(3), Archives of Oral Biology(1). Acta Pharmacol... more >>.