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Journal Article (Refereed)
April 2008

New stabilising groups for lateral lithiation of ortho-cresol derivatives and a new route to 2-substituted chromans

Wilkinson, J A & Raiber, E & Ducki, S 2008, 'New stabilising groups for lateral lithiation of ortho-cresol derivatives and a new route to 2-substituted chromans', Tetrahedron, 64, pp.6329-6333.

Abstract

2-(2-Methoxyethoxy)-toluene and 2-(2-dimethylaminoethoxy)-toluene have been lithiated using sec-BuLi under a variety of conditions and the laterally lithiated species trapped with electrophiles, including but-1-ene oxide, leading to a new synthesis of 2-ethylchroman.

Authors

SEEK Members

External Authors

Eun-Ang Raiber

Publication Details

Journal Name
Tetrahedron

Volume
64

Pagination
6329-6333.