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Published Conference Proceedings - Paper
March 2008

Inferring the function of genes from synthetic lethal mutations

Ray, O & Bryant, C 2008, Inferring the function of genes from synthetic lethal mutations, in: Barolli, L & XhafaF, F (eds.), 'Second International Conference on Complex, Intelligent and Software Intensive Systems', IEEE Computer Society, Los Alamitos, CA, USA, pp.667-671.

Abstract

Techniques for detecting synthetic lethal mutations in double gene deletion experiments are emerging as powerful tool for analysing genes in parallel or overlapping pathways with a shared function. This paper introduces a logic-based approach that uses synthetic lethal mutations for mapping genes of unknown function to enzymes in a known metabolic network. We show how such mappings can be automatically computed by a logical learning system called eXtended Hybrid Abductive Inductive Learning (XHAIL).

Authors

SEEK Members

External Authors

Oliver Ray

Editors:

Non-SEEK Editors

F XhafaF

L Barolli

Publication Details

Conference Proceedings
Bryant, C & Ray, eds. 2008, Second International Conference on Complex, Intelligent and Software Intensive Systems, IEEE Computer Society, Los Alamitos, CA, USA, pp.667-671.